Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

7.9K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
7.9K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implementation of 3D printing technology for complex spine revision cases that require multilevel anterior spinal support: Over 5-year experience in six cases and costs assessment.

Brain & spine·2026
Same author

Correction: The influence of casting techniques on the redisplacement risk of reduced distal radius fractures in adults.

Archives of orthopaedic and trauma surgery·2025
Same author

The influence of casting techniques on the redisplacement risk of reduced distal radius fractures in adults.

Archives of orthopaedic and trauma surgery·2025
Same author

Local delivery of lipid-based nanoparticles containing microbial nucleic acid for osteoimmunomodulation.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2025
Same author

Reliability and agreement of manual and automated morphological radiographic hip measurements.

Osteoarthritis and cartilage open·2024
Same author

Trained innate immunity modulates osteoblast and osteoclast differentiation.

Stem cell reviews and reports·2024

Related Experiment Video

Updated: Apr 27, 2026

Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography
04:24

Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography

Published on: November 22, 2017

10.5K

Electromagnetic fields do not affect bone micro-architecture in osteoporotic rats.

O P van der Jagt1, J C van der Linden1, J H Waarsing1

  • 1University Medical Centre Rotterdam, Department of Orthopaedics, Erasmus MC, PO Box 2040, 3000CA Rotterdam, the Netherlands.

Bone & Joint Research
|July 13, 2014
PubMed
Summary
This summary is machine-generated.

Electromagnetic fields (EMF) did not improve bone structure or fracture healing in osteoporotic rats. These findings suggest EMF treatment may be highly dependent on specific application methods, limiting its clinical potential for osteoporosis.

Keywords:
EMFIn Vivo MicroCTOsteoporosisSmall Animal Model

More Related Videos

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

3.6K
Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

7.4K

Related Experiment Videos

Last Updated: Apr 27, 2026

Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography
04:24

Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography

Published on: November 22, 2017

10.5K
Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

3.6K
Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

7.4K

Area of Science:

  • Biomedical Engineering
  • Orthopedics
  • Bone Research

Background:

  • Electromagnetic fields (EMF) are utilized for musculoskeletal disorders.
  • Emerging evidence suggests potential efficacy of EMF in osteoporosis treatment.
  • Further research is needed to validate EMF's role in bone health.

Purpose of the Study:

  • To investigate the effects of EMF on bone micro-architecture in osteoporotic and healthy rats.
  • To assess EMF's impact on fracture healing in a rat model.
  • To provide data for potential clinical trials in osteoporosis management.

Main Methods:

  • Ovariectomized (OVX) and sham-operated rats received EMF (20 Gauss) or no treatment.
  • Bilateral fibular osteotomies were performed to study fracture healing.
  • In vivo microCT scans evaluated bone changes and callus formation over six weeks.

Main Results:

  • EMF exposure did not alter cancellous or cortical bone in OVX or sham-OVX rats.
  • No significant difference in mineralized callus volume was observed around the osteotomy site with EMF treatment.
  • The study failed to replicate previously reported beneficial effects of EMF on bone.

Conclusions:

  • The study found no evidence that EMF influences bone mass in osteoporotic rats.
  • The lack of positive results may indicate high sensitivity of EMF treatment to specific experimental setups.
  • These findings pose a challenge for the clinical application of EMF in osteoporosis treatment.