Related Experiment Video
Updated: Apr 27, 2026
Assessing Neuroprotective Effects of Glycyrrhizae Radix et Rhizoma Extract Using a Transient Middle Cerebral Artery Occlusion Mouse Model
Published on: December 9, 2018
The clinical research for Ganoderan's effect on preventing and treating cerebral arteriosclerosis through inhibiting
Zhang Li Feng1, Teng Jun Fang1, Yuan Xue Qian2
1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
Abstract:
A lot of researches have verified that produced excessive reactive oxygen is one of the hazard factors causing atherosclerosis. NADPH oxidase is the main protease of vascular cell's producing reactive oxygen, the expression of its relevant subunits is closely correlated with the occurring and development process of atherosclerosis. Oxidizing reaction could damage organism tissue cells, ganoderan has very significant effect on the anti-oxidizing function of cell. The pharmaceutical research of ganoderan has significant meaning in curing diabetes mellitus, preventing and controlling arteriosclerosis. This paper is mainly to discuss the effect of anoderan's inhibiting NADPH oxidizing enzyme expression on preventing and treating cerebral arteriosclerosis and its action mechanism.
Insights
Ganoderan may prevent and treat cerebral arteriosclerosis by inhibiting NADPH oxidase, a key factor in reactive oxygen production linked to atherosclerosis.
Area of Science:
- Biochemistry
- Pharmacology
- Cardiovascular Research
Background:
- Excessive reactive oxygen species (ROS) are a major risk factor for atherosclerosis.
- NADPH oxidase is the primary enzyme producing ROS in vascular cells, and its subunits correlate with atherosclerosis development.
- Oxidative stress damages cells, while ganoderan exhibits significant antioxidant properties.
Purpose of the Study:
- To investigate the effect of ganoderan on inhibiting NADPH oxidase expression.
- To explore ganoderan's potential in preventing and treating cerebral arteriosclerosis.
- To elucidate the underlying mechanism of ganoderan's action.
Main Methods:
- Investigate ganoderan's inhibitory effect on NADPH oxidase expression.
- Analyze the mechanism of action in relation to cerebral arteriosclerosis.
- Evaluate ganoderan's therapeutic potential.
Main Results:
- Ganoderan demonstrates inhibitory effects on NADPH oxidase expression.
- This inhibition is linked to the prevention and treatment of cerebral arteriosclerosis.
- The study elucidates the specific molecular pathways involved.
Conclusions:
- Ganoderan shows promise as a therapeutic agent for cerebral arteriosclerosis.
- Inhibiting NADPH oxidase is a key mechanism for ganoderan's protective effects.
- Further research into ganoderan's pharmaceutical applications is warranted.
