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Updated: Jan 31, 2026

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
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[Mechanisms of resistance to molecular targeted drugs]

Naoya Fujita

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |July 15, 2014
    PubMed

    Insights

    Molecular targeted cancer therapies show promise but face challenges. This review explores kinase-targeted drugs and the molecular mechanisms behind drug resistance in cancer treatment.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Pharmacology

    Context:

    • Cancer treatments have advanced, yet significant challenges remain in prevention and therapy.
    • Molecular understanding of cell proliferation and survival underpins targeted cancer therapies.
    • Despite progress, molecular targeted drugs (e.g., EGFR-, ALK-, ROS1-, BRAF-targeted) have not achieved sufficient curative effects.

    Purpose:

    • To review recent advancements in the development of kinase-targeted cancer drugs.
    • To analyze the molecular mechanisms of both pre-existent (intrinsic) and acquired drug resistance.
    • To provide insights into overcoming therapeutic limitations in cancer treatment.

    Summary:

    • Kinase-targeted drugs represent a significant area of cancer therapy development.
    • Drug resistance, both intrinsic and acquired, poses a major obstacle to the efficacy of these targeted agents.
    • Understanding the molecular basis of resistance is crucial for improving patient outcomes.

    Impact:

    • This review highlights the need for strategies to overcome drug resistance in kinase-targeted cancer therapy.
    • It provides a foundation for developing more effective and durable cancer treatments.
    • Advances in understanding resistance mechanisms can guide the development of next-generation targeted therapies.

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