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Cryptosporidium hominis genotypes involved in increased incidence and clusters of cases, Navarra, Spain, 2012

I Fuentes1, C Martín2, X Beristain2

  • 1Servicio de Parasitología, Centro Nacional de Microbiología,Instituto de Salud Carlos III,Majadahonda,Spain.

Epidemiology and Infection
|July 15, 2014
PubMed

Insights

Two cryptosporidiosis outbreaks in Spain were linked to specific Cryptosporidium hominis subtypes. Investigations suggested children

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Molecular Biology

Background:

  • Increased incidence of cryptosporidiosis in Navarra, Spain, during summer 2012.
  • Cryptosporidiosis outbreaks pose public health challenges, particularly in community settings.

Purpose of the Study:

  • To investigate two distinct clusters of cryptosporidiosis infections in Navarra.
  • To identify the molecular subtypes of Cryptosporidium hominis involved in the outbreaks.
  • To explore potential exposure sources and the utility of genotyping in outbreak investigations.

Main Methods:

  • Molecular subtyping of Cryptosporidium hominis isolates.
  • Epidemiological interviews to identify potential exposure sources.
  • Case cluster analysis in urban and rural settings.

Main Results:

  • Two clusters identified: one urban (subtype IbA10G2R2) and one rural (subtype IaA18R3).
  • No single definitive exposure source, but children's pools implicated in both clusters.
  • Genotyping proved valuable for differentiating outbreak strains.

Conclusions:

  • Molecular subtyping is crucial for understanding cryptosporidiosis outbreak epidemiology.
  • Children's pools may represent a common risk factor for cryptosporidiosis transmission.
  • Genotyping tools can significantly aid future cryptosporidiosis outbreak investigations in Spain.
Keywords:
waterborne infections

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