Related Experiment Video
Updated: Apr 27, 2026

A High-content Assay for Monitoring AMPA Receptor Trafficking
Published on: January 28, 2019
miR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling
Mathieu Letellier1, Sara Elramah1, Magali Mondin1
11] University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, France. [2] CNRS, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, France. [3].
Abstract:
We investigated whether microRNAs could regulate AMPA receptor expression during activity blockade. miR-92a strongly repressed the translation of GluA1 receptors by binding the 3' untranslated region of rat GluA1 (also known as Gria1) mRNA and was downregulated in rat hippocampal neurons after treatment with tetrodotoxin and AP5. Deleting the seed region in GluA1 or overexpressing miR-92a blocked homeostatic scaling, indicating that miR-92a regulates the translation and synaptic incorporation of new GluA1-containing AMPA receptors.
More Related Videos
12:47Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates
Published on: March 20, 2014
09:49Combined Optogenetic and Freeze-fracture Replica Immunolabeling to Examine Input-specific Arrangement of Glutamate Receptors in the Mouse Amygdala
Published on: April 15, 2016