Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complement System01:27

Complement System

10.4K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
10.4K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

4.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.6K
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

786
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
786
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

1.8K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

746
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
746
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

801
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
801

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of ambient air pollution with cognitive functioning and markers of structural brain damage: The Maastricht study.

Environment international·2024
Same author

A global initiative to deliver precision health in diabetes.

Nature medicine·2024
Same author

Accelerometer-derived physical activity and sedentary time and cardiac biomarkers: The Maastricht Study.

Frontiers in cardiovascular medicine·2023
Same author

Cognitive Functioning in Survivors of Hematopoietic Stem Cell Transplantation Compared With a Matched General Population Sample-The Maastricht Observational Study of Late Effects After Stem Cell trAnsplantation Study.

Transplantation and cellular therapy·2023
Same author

In RA patients without prevalent CVD, incident CVD is mainly associated with traditional risk factors: A 20-year follow-up in the CARRÉ cohort study.

Seminars in arthritis and rheumatism·2022
Same author

Serum levels of autoantibodies against the angiotensin II type I receptor are not associated with serum dicarbonyl or AGE levels in patients with an aldosterone-producing adenoma.

Journal of human hypertension·2022

Related Experiment Video

Updated: Apr 27, 2026

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

1.7K

The complement system in human cardiometabolic disease.

E Hertle1, C D A Stehouwer1, M M J van Greevenbroek1

  • 1Department of Internal Medicine and CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre, PO Box 616, Maastricht 6200, MD, The Netherlands.

Molecular Immunology
|July 15, 2014
PubMed
Summary

The complement system, particularly C3, plays a significant role in obesity, diabetes, and cardiovascular disease (CVD). Different complement pathways show varied associations with metabolic health, highlighting its complex involvement in cardiometabolic disease.

Keywords:
Cardiovascular diseaseComplement systemDiabetesFatty liver diseaseInsulin resistanceObesity

More Related Videos

Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens
07:25

Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens

Published on: December 17, 2019

7.9K

Related Experiment Videos

Last Updated: Apr 27, 2026

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

1.7K
Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens
07:25

Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens

Published on: December 17, 2019

7.9K

Area of Science:

  • Immunology
  • Metabolic Disease Research
  • Cardiovascular Science

Background:

  • The complement system, a part of innate immunity, is increasingly recognized for its role in metabolic disorders.
  • Complement factors produced in adipose tissue link local inflammation to systemic metabolic issues like insulin resistance and dyslipidemia.
  • The system is implicated in the pathophysiology of liver damage, hyperglycemia, endothelial dysfunction, atherosclerosis, and fibrinolysis.

Purpose of the Study:

  • To review current evidence on the complement system's role in human cardiometabolic diseases.
  • To explore the association of C3, a central complement component, with metabolic derangements and cardiovascular risk.
  • To examine the distinct roles of different complement activation pathways in cardiometabolic disease processes.

Main Methods:

  • Review of existing human studies and evidence.
  • Analysis of associations between C3 concentrations and cardiometabolic risk factors.
  • Examination of data on the classical, lectin, alternative, and terminal complement pathways in relation to disease.

Main Results:

  • Elevated C3 concentrations are linked to insulin resistance, liver dysfunction, metabolic syndrome, type 2 diabetes, and CVD.
  • The lectin pathway shows potential benefits in type 2 diabetes and CVD.
  • Classical and alternative pathways are associated with unfavorable cardiometabolic traits, while the terminal pathway is implicated in liver disease and advanced CVD.

Conclusions:

  • The complement system has a complex and potentially causal role in human cardiometabolic disease.
  • Different complement activation pathways may have distinct roles in disease pathogenesis.
  • Further longitudinal studies are necessary to elucidate the specific contributions of complement components and activation pathways to cardiometabolic processes.