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Coarctation of the aorta: nonsurgical treatment using stent implantation
1Division of Cardiology, Department of Paediatrics, National University of Singapore, Lower Kent Ridge Road, Singapore. swee _chye _quek@nuhs.edu.sg.
Insights
Nonsurgical treatment using aortic coarctation (CoA) stenting in adults offers a less invasive alternative to surgery. This study shows good outcomes with significant pressure gradient reduction and no complications in four patients.
Area of Science:
- Cardiology
- Interventional Cardiology
- Vascular Surgery
Background:
- Coarctation of the aorta (CoA) is a congenital heart defect affecting 5%-8% of patients.
- Untreated significant CoA leads to severe morbidity and potential mortality.
- Surgical repair is the traditional treatment for CoA.
Purpose of the Study:
- To evaluate the efficacy of aortic coarctation (CoA) stenting as a nonsurgical treatment option.
- To present the treatment outcomes of adult patients who underwent CoA stenting.
- To explore a potential new treatment paradigm for CoA.
Main Methods:
- Retrospective review of four adult patients (20-41 years) with native CoA or restenosis.
- CoA stenting performed under general anaesthesia using Palmaz or Cheatham-Platinum stents.
- Pre- and post-procedure angiography and pressure gradient measurements.
Main Results:
- Successful stenting with significant reduction in pressure gradients across the coarctation site.
- Angiography confirmed relief of the aortic narrowing.
- Follow-up for 1-3 years revealed no reported complications.
Conclusions:
- Aortic coarctation (CoA) stenting is an effective nonsurgical treatment for adult patients.
- This less invasive approach demonstrates promising outcomes and safety.
- Catheter-based stenting may represent a paradigm shift in CoA management.
Introduction:
Coarctation of the aorta (CoA) accounts for 5%-8% of all congenital heart defects. If left untreated, most patients with significant CoA will have varying degrees of morbidity (e.g. hypertension, stroke, collateral formation and ventricular hypertrophy), possibly even mortality. Traditionally, treatment for this condition is surgical. Herein, we report stenting during catheterisation as an alternative nonsurgical treatment option for patients with CoA, and present the treatment outcomes of patients who underwent this treatment option.
Methods:
We retrospectively reviewed four patients (2 men and 2 women; age range 20-41 years) who underwent CoA stenting under general anaesthesia for the treatment of native CoA or restenosis of CoA at our institution. Three patients had a 40-mm Palmaz stent inserted, while one had a 39-mm Cheatham-Platinum covered stent inserted. Angiography and measurement of pressure gradients were performed before and after stent implantation to ensure good treatment outcomes.
Results:
The patients' treatment outcomes were good, with a significant reduction in pressure gradients across the narrowed segments. Angiography showed relief of CoA. The patients were followed up for 1-3 years, during which no complications were noted.
Conclusion:
This is the first reported series in Singapore on the nonsurgical treatment of CoAs in adult patients using stents during interventional cardiac catheterisation. This less invasive procedure may lead to a new paradigm shift with regard to the treatment of CoA.
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