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Pre-exposure prophylaxis accessibility research and evaluation (PrEPARE Study).

Helen L King1, Samuel B Keller, Michael A Giancola

  • 1University of California San Diego, 200 W. Arbor Dr., M/C 8425, La Jolla, CA, 92103, USA, h1king@ucsd.edu.

AIDS and Behavior
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Summary
This summary is machine-generated.

Few men who have sex with men (MSM) use HIV pre-exposure prophylaxis (PrEP) due to cost and side effect concerns. Addressing these barriers is crucial for increasing PrEP uptake among high-risk populations.

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Area of Science:

  • Public Health
  • Infectious Diseases
  • Clinical Pharmacy

Background:

  • HIV pre-exposure prophylaxis (PrEP) with tenofovir-emtricitabine (TDF-FTC) is effective but underutilized.
  • Men who have sex with men (MSM) are at high risk for HIV infection in the US.
  • Understanding barriers to PrEP use among MSM is critical for public health initiatives.

Purpose of the Study:

  • To identify barriers preventing the utilization of PrEP among men who have sex with men (MSM).
  • To assess the feasibility of prescribing PrEP in a real-world setting.

Main Methods:

  • A population-based sample of MSM seeking HIV testing were offered PrEP and education.
  • Eligible participants with recent unprotected sex and negative HIV status were invited to participate.
  • Surveys were administered to individuals who declined PrEP to identify barriers.

Main Results:

  • Despite offering PrEP to 416 eligible MSM, less than 0.5% received the medication.
  • Key barriers identified included cost, low perceived HIV risk, and concerns about daily medication adherence and long-term side effects.
  • Cost and side effect concerns were prominent among those declining participation.

Conclusions:

  • Significant barriers hinder PrEP uptake among MSM, necessitating targeted interventions.
  • Reducing the cost of TDF-FTC and improving education on potential side effects and HIV risks are essential.
  • Addressing these barriers can improve PrEP utilization and reduce HIV transmission in high-risk populations.