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Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Recent advances in childhood vitiligo.

Nanette B Silverberg1

  • 1Department of Dermatology, Mt. Sinai St. Luke's-Roosevelt Hospital Center, 1090 Amsterdam Avenue, Suite 11D, New York, NY 10025, USA.

Clinics in Dermatology
|July 15, 2014
PubMed
Summary

Recent advances improve childhood vitiligo management. This review covers new insights into pathogenesis, autoimmune and psychological comorbidities, and expanded therapeutic options for vitiligo.

Area of Science:

  • Dermatology
  • Immunology
  • Pediatrics

Background:

  • Vitiligo is an autoimmune skin condition affecting 0.5% globally, often starting in childhood.
  • Recent decades have seen significant progress in understanding and managing pediatric vitiligo.

Purpose of the Study:

  • To review recent advancements in the understanding and management of childhood vitiligo.
  • To highlight progress in pathogenesis, comorbidities, and treatment options.

Main Methods:

  • Literature review of recent advances in vitiligo research and clinical practice.
  • Synthesis of information on autoimmune and psychological aspects.
  • Compilation of updated therapeutic strategies.

Main Results:

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  • Enhanced understanding of vitiligo pathogenesis and associated autoimmune conditions.
  • Improved recognition and description of psychological comorbidities in children with vitiligo.
  • Expansion of available therapeutic interventions for managing vitiligo.

Conclusions:

  • Significant progress has been made in managing childhood vitiligo.
  • A comprehensive approach addressing pathogenesis, comorbidities, and diverse treatments is crucial.