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Updated: Apr 27, 2026
09:09
Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
Published on: June 23, 2020
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Folate-modified doxorubicin-loaded nanoparticles for tumor-targeted therapy
Guicun Wu1, Zuozhi Wang, Xiaoshan Bian
1Department of Oncology, Shandong Provincial Crops Hospital , Chinese People's Armed Forces, Jinan , China.
Pharmaceutical Biology
|July 15, 2014
Summary
Folate-modified nanoparticles effectively target cancer cells, significantly improving doxorubicin delivery and reducing tumor growth in vivo. This targeted drug delivery system shows promise for enhanced cancer therapy.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cancer Therapeutics
Background:
- Polymeric nanoparticles (NPs) are utilized as drug delivery vehicles.
- Surface modification with specific ligands enhances NP targeting to cancer cells.
Purpose of the Study:
- Develop a modified vector for receptor-mediated targeting of cancer cells.
- Increase intracellular uptake of doxorubicin (DOX) for improved cancer treatment.
Main Methods:
- Polymeric NPs were modified with folate (FA)-conjugated PEG-PE ligands.
- Evaluated physical-chemical characteristics, in vitro release, and cytotoxicity.
- Assessed in vivo therapeutic effects in mice bearing human nasopharyngeal carcinoma KB cells.
Main Results:
- FA-PEG-PE-modified NPs/DOX (FA-NPs/DOX) had a particle size of 229 nm and 86% drug loading.
- FA-NPs/DOX demonstrated significantly higher in vivo cytotoxicity compared to non-modified NPs/DOX and free DOX.
- Tumor volume was reduced to 812 mm³ with FA-NPs/DOX, versus 1290 mm³ and 1832 mm³ for controls.
Conclusions:
- The modified drug delivery system (DDS) effectively enhances cancer therapy efficacy.
- FA-NPs/DOX represent a promising carrier for doxorubicin delivery.
- The system shows potential for efficient antitumor therapy.
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