Ruptured and unruptured mycotic superior mesenteric artery aneurysms
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Updated: Apr 27, 2026

Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
Gaurav Sharma1, Marcus E Semel1, Edward A McGillicuddy1
1Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Abstract:
Aneurysms of the superior mesenteric artery (SMA) and branches thereof are uncommon but have a high rate of rupture and mortality relative to other visceral artery aneurysms. Historically, the predominant etiology has been infectious; with a renewed rise in intravenous drug abuse rates in the last decade, we hypothesize a resurgence in septic embolic complications may occur in the coming years. Here, we describe the presentation and management of 2 cases of intravenous drug users presenting with infectious endocarditis and SMA main trunk and branch aneurysms, one of which was ruptured. In addition, we review the literature on these rare clinical entities.
Insights
Septic aneurysms of the superior mesenteric artery (SMA) are rare but dangerous. Increased intravenous drug use may lead to more cases, highlighting the need for prompt diagnosis and treatment of these infectious aneurysms.
Area of Science:
- Vascular Surgery
- Infectious Diseases
- Radiology
Background:
- Aneurysms of the superior mesenteric artery (SMA) are rare visceral artery aneurysms with high rupture rates.
- Historically, infectious etiologies predominated, but recent increases in intravenous drug abuse (IVDA) suggest a potential resurgence of septic embolic complications.
Observation:
- Two cases of IVDA patients presenting with infectious endocarditis and SMA aneurysms are described.
- One of these cases involved a ruptured SMA aneurysm, emphasizing the critical nature of this condition.
Findings:
- Infectious endocarditis can lead to septic emboli, causing SMA aneurysms in IVDA patients.
- Prompt recognition and management are crucial due to the high risk of rupture and mortality associated with these aneurysms.
Implications:
- The rising rates of IVDA necessitate increased vigilance for septic embolic aneurysms of the SMA.
- Early diagnosis and intervention are vital for improving outcomes in patients with infectious SMA aneurysms.
- Further research into optimal management strategies for these rare but life-threatening conditions is warranted.
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