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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Apr 27, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
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The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

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Cancer cachexia: towards integrated therapeutic interventions.

Alessio Molfino1, Alessandra Formiconi, Filippo Rossi Fanelli

  • 1Sapienza University of Rome, Department of Clinical Medicine , Viale dell'Università, 37, 00185 Roma , Italy +39 06 499 72016 ; maurizio.muscaritoli@uniroma1.it.

Expert Opinion on Biological Therapy
|July 15, 2014
PubMed
Summary

Novel biological treatments, including monoclonal antibodies, show promise for cancer cachexia. Further research is needed to integrate these with nutritional and pharmacological strategies for improved patient outcomes.

Keywords:
biological therapiescachexiacancernutritional intervention

Related Experiment Videos

Last Updated: Apr 27, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
08:55

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

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Area of Science:

  • Oncology
  • Biochemistry
  • Pharmacology

Background:

  • Cancer cachexia is a complex metabolic syndrome characterized by muscle wasting and inflammation.
  • Current treatments for cancer cachexia have limitations, necessitating novel therapeutic approaches.
  • Biological treatments, such as monoclonal antibodies targeting inflammatory cytokines, are emerging as a potential strategy.

Discussion:

  • Monoclonal antibodies targeting cytokines offer an anti-inflammatory effect to combat muscle wasting in cancer cachexia.
  • Despite promise, biological treatments face limitations and require extensive clinical investigation.
  • Understanding the multifactorial pathogenesis of cancer cachexia is crucial for developing effective strategies.

Key Insights:

  • Biological treatments represent a novel approach to counteract cancer cachexia.
  • Further clinical investigation is essential for monoclonal antibodies targeting cytokines.
  • Multimodal strategies combining nutritional and pharmacological treatments are key.

Outlook:

  • New pharmacological therapies and conventional nutritional treatments will be integrated into a 'parallel pathway'.
  • This integrated approach aims for early recognition, prevention, and treatment of metabolic and nutritional derangements.
  • The ultimate goal is to improve quality of life, treatment tolerance, and survival rates for cancer patients.