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Related Concept Videos

Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

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Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
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Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
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Viral Meningitis01:18

Viral Meningitis

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Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
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Encephalitis l: Introduction01:19

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Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
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Related Experiment Video

Updated: Apr 27, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
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[Meningitis after a mouse bite].

Els M L Verhaegh1, Walid Moudrous, Anton G M Buiting

  • 1St. Elisabeth Ziekenhuis, Tilburg.

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|July 15, 2014
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Summary
This summary is machine-generated.

Lymphocytic choriomeningitis virus (LCMV) infection, a zoonotic disease from rodents, can cause viral meningitis. In healthy individuals, this LCMV infection is typically self-limiting.

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Area of Science:

  • Zoonotic diseases
  • Viral infections
  • Neurovirology

Background:

  • Lymphocytic choriomeningitis virus (LCMV) is a rodent-borne arenavirus causing zoonotic infections.
  • Human LCMV infections are frequently observed during autumn and winter.
  • Transmission occurs via inhalation of aerosols or direct contact with infected rodent excreta.

Observation:

  • A 37-year-old woman presented with severe headache, nausea, and vomiting.
  • The patient reported a mouse bite on her finger three weeks prior.
  • Neurological examination revealed no abnormalities, but cerebrospinal fluid analysis indicated viral meningitis.

Findings:

  • Immunofluorescence serological testing confirmed LCMV infection.
  • The clinical presentation and diagnostic findings were consistent with viral meningitis.

Implications:

  • LCMV infection following rodent contact can lead to viral meningitis.
  • The disease is generally self-limiting in immunocompetent individuals.
  • Highlights the importance of recognizing zoonotic transmission routes for arenaviral infections.