Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Huntington Disease l: Introduction

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show...

Investigation of Disease Outbreaks

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

Types of Reports I: Hand-off Report

Types of Reports I: Hand-off Report

A hand-off report, also known as a change-of-shift report, is a crucial nursing process that ensures the smooth transition of patient care responsibilities between nursing staff.
Following are the key components and categories of hand-off reports:
Purpose and Process:

Lysosomal Hydrolases

Lysosomal Hydrolases

Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Zero and ultra-short echo time and contrast-medium injection at 3-T to detect Achilles enthesitis and distinguish rheumatismal vs mechanical etiologies.

Clinical radiology·2025

Same author

Altered expression of cytokines, chemokines, growth factors, and soluble receptors in patients with colorectal cancer, and correlation with treatment outcome.

Cancer immunology, immunotherapy : CII·2024

Same author

Novel approach to analysis of the immune system using an ungated model of immune surface marker abundance to predict health outcomes.

Immunity & ageing : I & A·2022

Same author

Evaluation of the plantaris tendon: cadaver anatomy study with ultrasonographic and clinical correlation with tennis leg injury in 759 calves.

Skeletal radiology·2022

Same author

Immunology of Aging: the Birth of Inflammaging.

Clinical reviews in allergy & immunology·2021

Same author

Adipokines and the risk of active TB: a nested case-control study.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2021

Search research articles

Related Experiment Video

Updated: Apr 27, 2026

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Published on: February 14, 2011

Hoffa's disease: a report on 5 cases.

A Larbi¹, C Cyteval¹, M Hamoui²

¹Department of Musculoskeletal Imaging, Lapeyronie University Hospital, 371, avenue Gaston-Giraud-Dean, 34295 Montpellier cedex 5, France.

Diagnostic and Interventional Imaging

|July 15, 2014

Summary

This summary is machine-generated.

Hoffa's disease, a cause of anterior knee pain, involves inflammation and potential ossification of the infrapatellar fat pad. Diagnosis relies on MRI for inflammation and X-ray for chronic ossification.

Keywords:

Extra skeletal chondroma Hoffa's disease Infrapatellar fat pad Knee

Related Experiment Videos

Last Updated: Apr 27, 2026

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Published on: February 14, 2011

Area of Science:

Orthopedics
Radiology
Sports Medicine

Background:

Hoffa's disease, or infrapatellar fat pad syndrome, is an underdiagnosed cause of anterior knee pain.
Its exact pathophysiological mechanism remains unclear, but is linked to repetitive microtrauma.

Observation:

The study presents five cases of Hoffa's disease, with three in the initial stage and two in the chronic stage.
Symptoms include pain in the anterior compartment of the knee.

Findings:

Magnetic Resonance Imaging (MRI) is crucial for diagnosing inflammation of the fat pad in the initial stage.
In chronic cases, standard X-rays can reveal ossification of the fat pad, potentially leading to osteochondroma formation.

Implications:

Early diagnosis and understanding of Hoffa's disease pathophysiology are essential for effective management.
Further research is needed to elucidate the mechanisms and optimize treatment strategies for this condition.