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Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
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Related Experiment Video

Updated: Apr 27, 2026

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Neurorestorative therapy for stroke.

Jieli Chen1, Poornima Venkat2, Alex Zacharek1

  • 1Department of Neurology, Henry Ford Hospital , Detroit, MI , USA.

Frontiers in Human Neuroscience
|July 15, 2014
PubMed
Summary
This summary is machine-generated.

Subacute cell-based and pharmacological therapies show promise for stroke recovery. These treatments promote functional improvement by enhancing brain repair mechanisms like neurogenesis and white matter remodeling.

Keywords:
BMSCHUCBCmicroRNAneurorestorationniaspan

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Pharmacology

Background:

  • Ischemic stroke causes significant global mortality and long-term disability.
  • Effective therapeutic strategies for stroke recovery remain a critical research focus.
  • Preclinical evidence suggests subacute interventions can yield substantial functional improvements.

Purpose of the Study:

  • To review recent advancements in cell-based and pharmacological therapies for stroke recovery.
  • To explore molecular mechanisms driving restorative processes post-stroke.
  • To analyze the interplay of angiogenesis, neurogenesis, and white matter remodeling.

Main Methods:

  • Review of preclinical literature on bone marrow-derived mesenchymal stem cells (BMSCs) and umbilical cord blood cells.
  • Discussion of off-label pharmacological agents for stroke recovery.
  • Focus on molecular mechanisms including microRNA-mediated intercellular communication.

Main Results:

  • Cell-based and pharmacological therapies can promote functional recovery in subacute and chronic stroke phases.
  • These therapies enhance key restorative processes: angiogenesis, arteriogenesis, neurogenesis, and white matter remodeling.
  • MicroRNAs play a crucial role in regulating cell communication and brain plasticity after stroke.

Conclusions:

  • Subacute administration of BMSCs, cord blood cells, and specific drugs offers therapeutic potential for stroke.
  • Understanding the molecular underpinnings, including microRNA roles, is key to optimizing these restorative strategies.
  • Coordinated enhancement of neurogenesis, angiogenesis, and white matter repair is vital for stroke recovery.