Spontaneous whole blood platelet aggregation in insulin-dependent diabetes mellitus: an evaluation in an...

Spontaneous whole blood platelet aggregation (SWBPA) was examined in a case-control study, comparing a consecutive series of IDDM subjects (n = 30) to age, and sex matched controls. Subjects were free of platelet altering medications. Platelet aggregation was measured by the percent fall in single platelet count after 15 minutes of both shaking (SK) and magnetic stirring (ST). IDDM subjects showed a significantly greater percent fall in SK (means = 12.1) and ST (means = 34.0) compared to controls (SK means = 8.4, p less than 0.01; ST means = 24.3, p less than 0.05). Long-term repeat testing on 15 subjects (diabetics and non-diabetics) up to 4 months apart showed a correlation of 0.7 for SK, p less than 0.01 but only 0.4 for ST. In a further series of IDDM subjects (n = 176) those with macrovascular disease (n = 27) showed significantly greater percent fall in SK (p less than 0.05), and ST (p less than 0.05). We conclude that SWBPA is a simple useful epidemiological technique (shaking being more repeatable than stirring) which relates to both diabetes and macrovascular disease.