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Updated: Apr 27, 2026

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
Published on: March 1, 2024
Biomarkers of tolerance: searching for the hidden phenotype
Esperanza Perucha1, Irene Rebollo-Mesa2, Pervinder Sagoo3
1Section of Experimental Immunobiology, Division of Transplantation Immunology and Mucosal Biology, King's College London , London, UK ; Medical Research Centre for Transplantation, King's College London, Guy's Hospital , London, UK ; NIHR Biomedical Research Centre, Guy's and St Thomas' Hospital and King's College London , London, UK.
Abstract:
Induction of transplantation tolerance remains the ideal long-term clinical and logistic solution to the current challenges facing the management of renal allograft recipients. In this review, we describe the recent studies and advances made in identifying biomarkers of renal transplant tolerance, from study inceptions, to the lessons learned and their implications for current and future studies with the same goal. With the age of biomarker discovery entering a new dimension of high-throughput technologies, here we also review the current approaches, developments, and pitfalls faced in the subsequent statistical analysis required to identify valid biomarker candidates.
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