Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

7.9K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
7.9K
What is the Skeletal System?01:02

What is the Skeletal System?

45.6K
Overview
45.6K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

1.1K
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
1.1K
Bone Remodeling01:40

Bone Remodeling

34.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
34.3K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.8K
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant01:25

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

366
In patients with renal disease, dosage adjustments are necessary to maintain therapeutic plasma drug concentrations and prevent toxicity or subtherapeutic exposure. Renal impairment alters drug pharmacokinetics, especially in conditions like uremia, where changes such as prolonged elimination half-life and altered apparent volume of distribution can significantly affect drug disposition. These changes require careful modification of the dosing regimen to achieve the desired clinical...
366

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peri-renal and renal sinus fat accumulation and diabetic kidney disease in type 2 diabetes: A Japanese cohort study.

Diabetes research and clinical practice·2025
Same author

Association of severe stress with the onset of chronic kidney disease after the Great East Japan Earthquake: the Fukushima Health Management Survey.

Clinical and experimental nephrology·2025
Same author

Diverse combination of factors associated with the development of diabetic kidney disease among data-driven diabetes subtypes: analysis of the J-DREAMS registry.

Diabetologia·2025
Same author

Lubiprostone in chronic kidney disease: Insights into mitochondrial function and polyamines from a randomized phase 2 clinical trial.

Science advances·2025
Same author

Changes in peripheral blood test results among adults in the six years following the Great East Japan Earthquake: the Fukushima Health Management Survey.

Fukushima journal of medical science·2025
Same author

Impact of Changes in Lifestyle and Psychological Factors on the Incidence of Metabolic Syndrome after the Great East Japan Earthquake: Follow-up of the Fukushima Health Management Survey.

Journal of atherosclerosis and thrombosis·2024

Related Experiment Video

Updated: Apr 27, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

7.4K

Uremic osteoporosis.

Junichiro J Kazama1, Yoshiko Iwasaki2, Masafumi Fukagawa3

  • 1Division of Blood Purification Therapy, Niigata University Medical and Dental Hospital , Niigata, Japan.

Kidney International Supplements
|July 15, 2014
PubMed
Summary

Chronic kidney disease (CKD) patients face a high hip fracture risk due to factors beyond falls. New research suggests

Keywords:
bone elastic mechanical propertieship fractureosteoporosisuremic toxin

More Related Videos

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

3.6K
Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

1.6K

Related Experiment Videos

Last Updated: Apr 27, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

7.4K
Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

3.6K
Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

1.6K

Area of Science:

  • Nephrology and Orthopedics
  • Bone Biology and Disease

Background:

  • Chronic kidney disease-related mineral and bone disorder (CKD-MBD) involves bone abnormalities, but hip fracture risk in CKD patients is complex.
  • While falls contribute, other mechanisms are involved in the elevated hip fracture risk observed in CKD populations.
  • The relationship between bone mineral density and fracture risk differs in CKD patients compared to the general population.

Approach:

  • Investigated the mechanical properties of long bones in experimental CKD animal models.
  • Examined the correlation between bone elasticity, bone biochemical changes, and kidney function.
  • Assessed the effect of the oral absorbent AST-120 on bone material properties and elasticity in CKD animals.

Key Points:

  • Bone elasticity in CKD animals inversely correlated with kidney function, indicating impaired bone material properties.
  • Deterioration of bone elasticity was significantly linked to bone biochemical alterations.
  • AST-120 administration prevented the decline in bone elasticity and material properties.

Conclusions:

  • Uremic toxins appear to degrade bone material properties, leading to reduced bone elasticity.
  • This 'uremic osteoporosis' is distinct from CKD-MBD and may be a primary driver of increased hip fracture risk in CKD patients.
  • Understanding uremic osteoporosis offers new insights into managing fracture risk in CKD.