Related Experiment Video
Updated: Apr 27, 2026

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion
Published on: April 2, 2020
CCR7: roles in cancer cell dissemination, migration and metastasis formation
Daniel F Legler1, Edith Uetz-von Allmen1, Mark A Hauser1
1Biotechnology Institute Thurgau (BITg) at the University of Konstanz, Kreuzlingen, Switzerland.
Abstract:
The CC-chemokine receptor 7 (CCR7) coordinates the migration of cancer cells as well as immune cells towards lymphatic organs where its two ligands CCL19 and CCL21 are constitutively expressed. Here we provide a topological model of CCR7, which belongs to the class A of G-protein coupled, seven-transmembrane spanning receptors, and describe how CCR7 expression is regulated. We focus on its role in cancer cell migration and metastasis formation and discuss how cancer cells can utilize CCR7 or its ligands to escape from immune surveillance.
More Related Videos
Related Concept Videos
Cancer Cell Migration through Invadopodia
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Cell Migration
Cell Migration
Chemotaxis and Direction of Cell Migration
Small GTPases - Ras and Rho
Three regulatory proteins control their activity:

