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Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound
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Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound

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Protective effect of external ventricular drainage on cerebral vasospasm. A retrospective study on aneurysmal SAH

G M Della Pepa1, A Scerrati1, A Albanese1

  • 1Institute of Neurosurgery, Catholic University of Rome, Largo A. Gemelli 8, 00168, Italy.

Clinical Neurology and Neurosurgery
|July 15, 2014
PubMed

Insights

External ventricular drainage (EVD) can reduce the risk of cerebral vasospasm (VS) after aneurysmal subarachnoid hemorrhage (SAH). This study found lower VS incidence in patients treated with EVD for hydrocephalus.

Area of Science:

  • Neurosurgery
  • Neurology
  • Critical Care Medicine

Background:

  • Cerebral vasospasm (VS) significantly worsens outcomes after aneurysmal subarachnoid hemorrhage (SAH).
  • Cerebrospinal fluid (CSF) diversion is proposed to prevent VS, but evidence remains debated.
  • External ventricular drainage (EVD) is standard for managing post-hemorrhagic hydrocephalus.

Purpose of the Study:

  • To evaluate the effectiveness of EVD in reducing clinical and radiological VS incidence.
  • To assess EVD's impact on VS in patients undergoing endovascular SAH treatment.

Main Methods:

  • Retrospective analysis of 141 patients with aneurysmal SAH treated endovascularly.
  • Comparison of VS incidence between 80 patients with EVD for hydrocephalus and 61 patients without EVD.

Main Results:

  • VS occurred in 8.75% of patients with EVD versus 22.95% without EVD.
  • Patients without EVD showed a higher prevalence of VS, particularly in lower Fisher grades.

Conclusions:

  • CSF drainage via EVD appears to reduce the risk of vasospasm in endovascularly treated aneurysmal SAH patients.
  • EVD may be a beneficial intervention for preventing VS post-SAH.
Abstract

Keywords:
External ventricular drainageSAHVasospasm

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