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Histamine catabolism in proliferating skin.
W A Fogel1, M Swiderska, C Maslinski
1Department of Biogenic Amines, Polish Academy of Sciences, Lodz, Poland.
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|April 1, 1989
Summary
Histamine levels and histamine N-methyltransferase activity decrease with epidermal proliferation, while diamine oxidase activity increases. These levels then rise above normal during epidermal hyperplasia.
Area of Science:
- Biochemistry
- Dermatology
- Pharmacology
Background:
- Histamine plays a role in various physiological processes, including skin inflammation and proliferation.
- Enzymes like histamine N-methyltransferase (HMT) and diamine oxidase (DAO) are crucial for histamine degradation.
Purpose of the Study:
- To investigate the changes in histamine content and its degradation enzyme activities in guinea pig skin during epidermal proliferation and hyperplasia.
Main Methods:
- Guinea pig skin was stimulated to induce epidermal proliferation and hyperplasia.
- Histamine content was measured.
- Enzyme activities of HMT and DAO were assayed in stripped skin samples.
Main Results:
- Histamine content and HMT activity were reduced in skin with increased epidermal proliferation compared to unstimulated skin.
- Histamine content and HMT activity were elevated above normal levels when the epidermis became hyperplastic.
- DAO activity exhibited an inverse pattern to histamine content and HMT activity.
Conclusions:
- Epidermal proliferation and hyperplasia significantly alter histamine metabolism in guinea pig skin.
- The observed changes in histamine and its enzyme activities suggest a dynamic regulatory process during skin growth and thickening.