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[Apelin activity in patients with essential hypertension nd accompanied prediabetes and type 2 diabetes mellitus]

A V Demidenko

    Georgian Medical News
    |July 15, 2014
    PubMed

    Insights

    Apelin levels are significantly elevated in patients with essential hypertension, particularly those with type 2 diabetes or pre-diabetes. This suggests apelin plays a role in developing glucose metabolism issues in hypertension.

    Area of Science:

    • Endocrinology
    • Metabolic Disorders
    • Cardiovascular Research

    Background:

    • Essential hypertension is a prevalent condition often associated with metabolic disturbances.
    • Carbohydrate disorders, including pre-diabetes and type 2 diabetes, frequently coexist with hypertension.
    • The role of specific peptide hormones, like apelin, in the interplay between hypertension and metabolic dysfunction requires further elucidation.

    Purpose of the Study:

    • To investigate the activity and levels of apelin in patients with essential hypertension.
    • To determine the correlation between apelin levels and the presence of carbohydrate disorders (pre-diabetes and type 2 diabetes) in hypertensive individuals.
    • To explore the potential involvement of apelin in the pathogenesis of gluco-metabolic disorders within the context of essential hypertension.

    Main Methods:

    • Clinical and laboratory investigations were conducted on 136 patients diagnosed with essential hypertension.
    • Prevalence of comorbid type 2 diabetes and pre-diabetes was assessed in the study cohort.
    • Apelin levels were measured and analyzed in relation to carbohydrate metabolism markers and hypertension status.

    Main Results:

    • A significant increase in apelin levels was observed in the overall group of hypertensive patients.
    • Patients with comorbid type 2 diabetes exhibited the most pronounced elevation in apelin levels.
    • Significant correlations were found between apelin levels and various components of the carbohydrate pool.

    Conclusions:

    • Apelin is significantly elevated in patients with essential hypertension, with a marked increase in those also having type 2 diabetes or pre-diabetes.
    • The observed correlations suggest that apelin is implicated in the development of gluco-metabolic disorders in the setting of essential hypertension.
    • These findings highlight apelin as a potential biomarker and therapeutic target in managing hypertensive patients with coexisting carbohydrate abnormalities.

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