Etiology as a predictor of morbidity after convulsive status epilepticus in children

CSE is the most common childhood neurological emergency in developed countries, which can lead to neuro cognitive sequel and death with different hazards and outcome. The majority of authors'agreed that etiology is the main determinant of morbidity, but different studies reported different etiology groups as predictors of the poor outcome. Present study was conducted to evaluate predictive value of etiology in post CSE morbidity. Prospective, hospital-based study was performed in Tbilisi. Patients, aged from one month to 18 years with CSE, admitted to the emergency department of M. Iashvili Children's Central Hospital from March 2007 to March 2012 were included. The short-term outcome of CSE was evaluated after 30 days from admission and it was classified into three categories: unchanged neurologic status, neurological consequences (new neurologic deficit compared to the condition before CSE), and lethal outcome. 48 children aged one month- 18 years were analyzed. In our study acute symptomatic, remote symptomatic and progressive encephalopathy were associated with higher morbidity. Progressive encephalopathy is the most frequent etiology group which led to develop new neurological sequel after CSE and long duration of CSE. According to our data we conclude that children with idiopathic or febrile CSE have a favorable outcome. While acute symptomatic etiology group mostly was associated and statistical significant association were found with progressive encephalopathy and development morbidity after CSE. According to our data we conclude that children with idiopathic or febrile CSE have a favorable outcome. While progressive encephalopathy lead to develop morbidity after CSE.