Related Experiment Video
Updated: Apr 27, 2026

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices
Published on: August 11, 2021
Changes in monoamine oxidase activity in hepatic injury: a review
Abstract:
This review focuses on multiplicity of monoamine oxidase (MAO) activity in rat hepatic injury. MAO play a major role in the metabolism of biogenic amines. Stress such as immobilization stress (IMMO) or cold stress changes the multiple forms of MAO activity in rat liver. Thyroid hormone-inducible MAO inhibitor may play some role in regulating the MAO activity in rat liver. Carcinogen such as dimethylnitrosamine (DEN) might change the proportions of the forms of MAO activity in tumor cells. This compound is selective to and an irreversible inhibitor of MAO-B. These changes may account for the multiplicity of MAO by hepatic injury.
Related Concept Videos
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Hepatic Encephalopathy
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Drugs Affecting Neurotransmitter Synthesis
Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

