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Micronuclei in breast aspirates. Is scoring them helpful?
A Hemalatha1, T N Suresh, M L HarendraKumar
1Department of Pathology, Sri Devaraj Urs Medical College, Tamaka, Kolar, Karnataka, India.
Journal of Cancer Research and Therapeutics
|July 16, 2014
Summary
Micronuclei scoring in breast tissue shows a significant increase from benign fibroadenomas to infiltrating ductal carcinoma. This suggests micronuclei can serve as a biomarker for genotoxic damage in breast cancer diagnosis.
Area of Science:
- Oncology
- Cytopathology
- Genetics
Background:
- Micronuclei scoring is a validated method for assessing genotoxic and chromosomal damage.
- Understanding micronuclei frequency in breast lesions aids in cancer risk assessment.
Purpose of the Study:
- To quantify spontaneous micronuclei in fibroadenomas and infiltrating ductal carcinoma.
- To compare micronuclei frequency across different grades of infiltrating ductal carcinoma and benign tumors.
Main Methods:
- Analysis of May Grunwald Giemsa stained fine needle aspiration cytology smears.
- Micronuclei scoring in 40 fibroadenoma and 40 infiltrating ductal carcinoma cases.
- Statistical comparison using the Student's t-test.
Main Results:
- Mean micronuclei count in fibroadenomas was 1.8 ± 1.9.
- Mean micronuclei counts increased with tumor grade: Grade I (12.1 ± 9.2), Grade II (27.4 ± 27.2), and Grade III (100 ± 36.5).
Conclusions:
- A clear trend of increasing micronuclei was observed from benign fibroadenomas to higher grades of infiltrating ductal carcinoma.
- Micronuclei scoring is a valuable biomarker for breast carcinoma detection on cytology smears.
