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Chelation therapy after the trial to assess chelation therapy: results of a unique trial

Maria D Avila1, Esteban Escolar, Gervasio A Lamas

  • 1Columbia University Division of Cardiology, Mount Sinai Medical Center, Miami Beach, Florida, USA.

Current Opinion in Cardiology
|July 16, 2014
PubMed

Insights

EDTA chelation therapy shows promise for post-myocardial infarction (MI) patients, significantly reducing adverse cardiovascular events. Diabetic patients experienced even greater benefits, including reduced mortality, suggesting a potential new treatment avenue.

Area of Science:

  • Cardiovascular Medicine
  • Chelation Therapy
  • Clinical Trials

Background:

  • EDTA chelation therapy is used off-label for atherosclerosis.
  • Large-scale randomized trials are needed to evaluate its efficacy.

Purpose of the Study:

  • To review the results of the first large-scale randomized trial of EDTA chelation therapy.
  • To assess the safety and efficacy of EDTA-based chelation infusions in post-myocardial infarction (MI) patients.

Main Methods:

  • A $30 million National Institutes of Health-funded randomized trial.
  • Involved 1708 post-myocardial infarction (MI) patients.

Main Results:

  • An 18% reduction in a combined endpoint of death, MI, stroke, revascularization, or angina hospitalization (P=0.035).
  • Diabetic patients showed a 41% relative risk reduction (P=0.0002) and a 43% reduction in total mortality (P=0.011).
  • Favorable safety data were observed; reduced oxidative stress is a proposed mechanism.

Conclusions:

  • EDTA chelation may be a well-tolerated and effective treatment for post-MI patients.
  • Further replication and mechanistic studies are warranted before widespread implementation.
Abstract

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