Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

6.2K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
6.2K
Structure and Function of Platelets01:18

Structure and Function of Platelets

6.9K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
6.9K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

2.7K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
2.7K
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

1.6K
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
1.6K
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

5.9K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
5.9K
Metastasis02:30

Metastasis

5.4K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A microfluidic platform for isolating functional mitochondria and restoring bioenergetic activity in hypoxia-injured cardiomyocytes.

International journal of biological macromolecules·2026
Same author

Essential but neglected: securing the global supply of human hyperimmune immunoglobulins.

The Lancet. Haematology·2026
Same author

Platelet membrane-coated nanoparticles: Bioengineering principles, quality control, and translational opportunities.

APL bioengineering·2026
Same author

Real-world outcomes of patients with multiple myeloma who reach third-line therapy: a Canadian report.

Blood neoplasia·2026
Same author

Immune dysregulation in mania: A proof-of-concept platelet proteomics study.

Psychiatry and clinical neurosciences·2026
Same author

Platelet-derived and platelet secretome biotherapies for precision neuromedicine.

Trends in molecular medicine·2026

Related Experiment Video

Updated: Apr 27, 2026

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
09:46

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells

Published on: December 27, 2017

19.4K

Platelets effects on tumor growth.

Hadi A Goubran1, Julie Stakiw1, Mirjana Radosevic2

  • 1Saskatoon Cancer Centre and Division of Oncology, Department of Medicine, College of Medicine, University of Saskatchewan, SK, Canada.

Seminars in Oncology
|July 16, 2014
PubMed
Summary

Platelets, crucial for healing, also significantly impact cancer progression and metastasis. Inhibiting platelet activity offers a promising new strategy for cancer treatment.

More Related Videos

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.7K
Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
09:13

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

Published on: April 6, 2017

11.3K

Related Experiment Videos

Last Updated: Apr 27, 2026

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
09:46

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells

Published on: December 27, 2017

19.4K
Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.7K
Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
09:13

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

Published on: April 6, 2017

11.3K

Area of Science:

  • Hematology
  • Oncology
  • Cell Biology

Background:

  • Platelets are small, anucleate blood cells derived from megakaryocytes.
  • Historically, platelets were recognized for hemostasis but possess broader roles in tissue repair and cancer.
  • Tumor cells interact with platelets, influencing thrombosis and cancer progression.

Purpose of the Study:

  • To review the multifaceted roles of platelets in cancer.
  • To explore platelet involvement in primary tumor sites and metastasis.
  • To highlight the therapeutic potential of targeting platelets in cancer treatment.

Main Methods:

  • Literature review of studies on platelet-cancer interactions.
  • Analysis of platelet roles in tumor microenvironment and metastasis.
  • Discussion of therapeutic strategies targeting platelets.

Main Results:

  • Tumor cells induce platelet aggregation (TCIPA), a trigger for cancer-associated thrombosis.
  • Platelets promote tumor cell proliferation via direct interaction and growth factor release.
  • Platelets facilitate tumor cell intravasation, migration, and extravasation, aiding metastasis.

Conclusions:

  • Platelets are key players in cancer progression, from primary tumor growth to distant metastasis.
  • Targeting platelets and their components presents a novel and attractive therapeutic avenue for cancer.
  • Understanding platelet functions in cancer is crucial for developing effective anti-cancer strategies.