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Updated: Apr 27, 2026
Novel Sequence Discovery by Subtractive Genomics
Published on: January 25, 2019
siRNA: novel therapeutics from functional genomics
1a Department of Food Quality Assurance , College of Food Processing Technology and Bio Energy, Anand Agricultural University , Anand 388 110 , Gujarat , India.
Small interfering RNA (siRNA) has become a potent therapeutic tool, enabling gene regulation for drug discovery. This review covers siRNA gene silencing mechanisms, therapeutic potential, and current challenges.
Area of Science:
- Molecular Biology
- Genetics
- Pharmacology
Background:
- RNA interference (RNAi) research has elucidated siRNA-mediated gene silencing mechanisms.
- Small interfering RNA (siRNA) has emerged as a significant therapeutic modality.
- siRNA offers potential for regulating virtually any disease-associated gene in the human genome.
Purpose of the Study:
- To review the fundamentals of siRNA-mediated gene silencing.
- To discuss the transformation of functional genomics into novel therapeutics using siRNA.
- To highlight current challenges and future directions for siRNA-based therapies.
Main Methods:
- Literature review of RNA interference and siRNA technology.
- Analysis of siRNA's role in gene silencing and therapeutic applications.
- Examination of advancements in in vivo siRNA delivery.
Main Results:
- siRNA is a powerful tool for in vitro target screening and validation.
- Progress in in vivo siRNA delivery enhances therapeutic expectations.
- siRNA enables unprecedented opportunities for drug discovery by regulating disease-associated genes.
Conclusions:
- siRNA-based drugs show promise as a future therapeutic 'magic bullet'.
- Overcoming current hurdles is essential for advancing siRNA therapeutics.
- Further research is needed to fully realize the potential of siRNA in medicine.
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