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IL-6 572 C/G, 190 C/T, and 174 G/C gene polymorphisms in children's malnutrition

Cristina O Marginean1, Claudia Banescu, Septimiu Voidazan

  • 1*Pediatrics Clinic I †Department of Genetics ‡Department of Epidemiology, University of Medicine and Pharmacy of Târgu Mureş, Romania.

Journal of Pediatric Gastroenterology and Nutrition
|July 16, 2014
PubMed

Insights

Children with malnutrition show higher frequencies of IL-6 174 G allele carriers. The IL-6 190 TT genotype appears protective against malnutrition in children. Specific combined genotypes were also more frequent in malnourished children.

Area of Science:

  • Genetics and Molecular Biology
  • Pediatrics
  • Nutritional Science

Background:

  • Childhood malnutrition remains a significant global health issue.
  • Genetic factors, including cytokine gene polymorphisms, may influence susceptibility to malnutrition.
  • Interleukin-6 (IL-6) is a key inflammatory cytokine with known roles in various physiological processes.

Purpose of the Study:

  • To investigate the association between polymorphisms in the interleukin-6 (IL-6) genes at positions 572, 190, and 174 and the occurrence of malnutrition in hospitalized children.
  • To identify specific IL-6 genotypes that correlate with malnutrition and its clinical indicators.

Main Methods:

  • A case-control study involving 283 hospitalized children, divided into a control group (n=110) and a malnourished group (n=173).
  • Genotyping for IL-6 polymorphisms at positions 572 (C/G), 190 (C/T), and 174 (G/C).
  • Assessment of anthropometric indicators (BMI, mid-upper arm circumference, tricipital skinfold thickness) and serum albumin levels.

Main Results:

  • The GG and CG genotypes of the IL-6 174 gene were significantly more frequent in malnourished children (P = 0.0001).
  • The CT heterozygous genotype of the IL-6 190 gene was also more prevalent in the malnourished group (P = 0.003).
  • The IL-6 190 TT genotype demonstrated a protective effect against malnutrition (P = 0.0001).
  • Malnutrition indicators (BMI, MUAC, TST, low albumin) correlated with specific IL-6 genotypes (IL-6 572/174 GG/CG and IL-6 190 CT).

Conclusions:

  • Carriage of the IL-6 174 G allele (GG and CG genotypes) is associated with a higher risk of malnutrition in children.
  • The IL-6 190 TT genotype appears to confer a protective effect against childhood malnutrition.
  • Specific combinations of IL-6 polymorphisms (e.g., GG/CT/CG at 572/190/174) were found to be more common in malnourished children, suggesting a complex genetic influence.
Abstract

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