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Published on: September 1, 2015
Extra sensory perception: the role of Gpr receptors in the kidney
1Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Purpose Of Review:
This review will summarize recent literature highlighting the roles of sensory Gpr receptors and their roles in renal function.
Recent Findings:
Chemoreceptors play important roles in renal physiology wherein they modulate renal function in response to ligands from a variety of sources.
Summary:
As specialized chemical detectors, chemoreceptors in the kidney monitor the level of a variety of chemical ligands in the body and adjust renal function accordingly. In addition to olfactory receptors and taste receptors, G-protein coupled receptors of the orphan Gpr family are now being found to play a 'sensory' role in renal physiology. Identifying the physiological roles of these receptors and elucidating the cell biology underlying these signaling pathways can give us novel insights into renal function.
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