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Dietary influences on cell proliferation in bone marrow
P B Dunki Jacobs1, M Ruevekamp, G A Hart
1Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam.
European Journal of Cancer & Clinical Oncology
|June 1, 1989
Summary
Protein-calorie malnutrition in rats reduced bone marrow cell proliferation. Nutritional replenishment rapidly restored cell cycle distribution, suggesting potential marrow protection for malnourished patients before therapy.
Area of Science:
- Biomedical Science
- Cell Biology
- Nutritional Science
Background:
- Protein-calorie malnutrition impacts cellular processes.
- Bone marrow stem cell distribution across the cell cycle is crucial for hematopoiesis.
Purpose of the Study:
- To investigate the effects of malnutrition on bone marrow stem cell cycle distribution in rats.
- To assess the reversibility of these effects upon nutritional replenishment.
Main Methods:
- Rats were subjected to oral dietary protein-calorie malnutrition for 5 and 14 days.
- Cell cycle distribution of bone marrow cells was analyzed.
- Hemoglobin, platelet, and leukocyte counts were monitored.
Main Results:
- Malnutrition increased G0/G1 phase cells and decreased S phase cells.
- Nutritional replenishment rapidly restored S phase cells and decreased G0/G1 phase cells.
- Leukocyte counts increased significantly after short-term replenishment.
Conclusions:
- Short-term malnutrition decreases bone marrow cell proliferation.
- Bone marrow cells demonstrate rapid recovery following nutritional replenishment.
- Nutritional replenishment before therapy may protect bone marrow in malnourished cancer patients.