Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

18
Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
18
Flail Chest-I01:24

Flail Chest-I

1.2K
Overview of Flail Chest
Flail chest is a severe and potentially life-threatening condition characterized by the fracture of three or more adjacent ribs in multiple places. It is most commonly caused by direct impacts and trauma, such as motor vehicle accidents or injuries from a steering wheel impact. It can also occur due to falls in elderly individuals with osteoporosis, or assaults involving sharp objects.
Pathophysiology
The pathophysiology of flail chest is complex, involving fractures of...
1.2K
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

40
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
40
Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

14
DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...
14
Flail Chest-II01:26

Flail Chest-II

998
Managing flail chest, a condition characterized by a segment of the chest wall moving independently from the rest of the thoracic cage, requires a comprehensive approach. It includes a thorough assessment of the patient's condition, a diagnostic evaluation to determine the extent of the injury, and the implementation of appropriate medical interventions tailored to the individual's needs.
Assessment:
1. Clinical Evaluation:
History:
998
Herniated Intervertebral Disc l: Introduction01:29

Herniated Intervertebral Disc l: Introduction

32
Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
32

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A protocol for the development of a core outcome set for adults with depression.

Journal of clinical epidemiology·2025
Same author

Evaluating the effectiveness of minimum chlorate technologies employed by manufacturers of skim milk powder from both microbiological quality and chemical residue perspectives.

Journal of dairy science·2024
Same author

Effects of ganaxolone on non-seizure outcomes in CDKL5 Deficiency Disorder: Double-blind placebo-controlled randomized trial.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2024
Same author

qPCR assay optimisation for a clinical study comparing oral health risk in Rett syndrome.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2024
Same author

Adapting a measure of gross motor skills for individuals with CDKL5 deficiency disorder: A psychometric study.

Epilepsy research·2024
Same author

Emotional and behavioral outcomes among youths with mental disorders during the first Covid lockdown and school closures in England: a large clinical population study using health care record integrated surveys.

Social psychiatry and psychiatric epidemiology·2023

Related Experiment Video

Updated: Apr 27, 2026

A Contusive Model of Unilateral Cervical Spinal Cord Injury Using the Infinite Horizon Impactor
07:28

A Contusive Model of Unilateral Cervical Spinal Cord Injury Using the Infinite Horizon Impactor

Published on: July 24, 2012

19.3K

The whiplash syndrome.

J Downs1, L Twomey1

  • 1Western Australian Institute of Technology.

The Australian Journal of Physiotherapy
|July 16, 2014
PubMed
Summary

This review explores cervical spine injuries from flexion-extension movements, detailing their pathology and clinical signs. A treatment plan is proposed based on this evidence for effective management.

Area of Science:

  • Orthopedics
  • Biomechanics
  • Spinal Cord Injury Research

Background:

  • Cervical spine injuries, particularly those involving flexion-extension mechanisms, represent a significant clinical challenge.
  • Understanding the biomechanical forces and resulting pathological changes is crucial for effective patient management.

Purpose of the Study:

  • To review the biomechanics of cervical spine flexion-extension injuries.
  • To elucidate the associated pathological and clinical features.
  • To propose a rational treatment regime based on current evidence.

Main Methods:

  • Comprehensive literature review of biomechanical studies on cervical spine injuries.
  • Analysis of pathological and clinical findings reported in relevant research.
  • Synthesis of evidence to formulate a treatment strategy.

More Related Videos

A Novel Vertebral Stabilization Method for Producing Contusive Spinal Cord Injury
09:24

A Novel Vertebral Stabilization Method for Producing Contusive Spinal Cord Injury

Published on: January 5, 2015

19.0K
Establishing a Mouse Contusion Spinal Cord Injury Model Based on a Minimally Invasive Technique
07:17

Establishing a Mouse Contusion Spinal Cord Injury Model Based on a Minimally Invasive Technique

Published on: September 7, 2022

7.0K

Related Experiment Videos

Last Updated: Apr 27, 2026

A Contusive Model of Unilateral Cervical Spinal Cord Injury Using the Infinite Horizon Impactor
07:28

A Contusive Model of Unilateral Cervical Spinal Cord Injury Using the Infinite Horizon Impactor

Published on: July 24, 2012

19.3K
A Novel Vertebral Stabilization Method for Producing Contusive Spinal Cord Injury
09:24

A Novel Vertebral Stabilization Method for Producing Contusive Spinal Cord Injury

Published on: January 5, 2015

19.0K
Establishing a Mouse Contusion Spinal Cord Injury Model Based on a Minimally Invasive Technique
07:17

Establishing a Mouse Contusion Spinal Cord Injury Model Based on a Minimally Invasive Technique

Published on: September 7, 2022

7.0K

Main Results:

  • Detailed examination of the forces involved in flexion-extension cervical spine injuries.
  • Correlation of specific injury mechanisms with distinct pathological and clinical manifestations.
  • Identification of key factors influencing injury severity and patient outcomes.

Conclusions:

  • A thorough understanding of cervical spine injury biomechanics is essential.
  • Pathological and clinical features provide a basis for targeted treatment approaches.
  • Evidence-based treatment regimes can optimize outcomes for patients with these injuries.