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Updated: Apr 27, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Diagnostic features of retinal nerve fiber layer rotation in skew deviation using optical coherence tomography
John J Chen1, Randy H Kardon, Reid A Longmuir
1Department of Ophthalmology and Visual Sciences (JJC, RHK, RAL), University of Iowa, Iowa City, Iowa; and Department of Veterans Affairs (RHK), Veteran's Affairs Medical Center, Iowa City, Iowa.
Abstract:
A 41-year-old woman with skew deviation had cyclotorsion of both eyes. This resulted in a falsely low probability plot of retinal nerve fiber layer thickness in adjacent clock hours on optical coherence tomography (OCT) due to displacement of the retinal nerve fiber layer peaks. Ocular cyclotorsion may cause misinterpretation of OCT probability plots. OCT retinal nerve fiber layer plots also may be used to objectively quantify the degree of ocular cyclotorsion.

