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Related Experiment Video

Updated: Apr 27, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
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Orbital Epithelioid Sarcoma: A Case Report.

Lama L Jurdy1, Leo E Blank, Johannes Bras

  • 1Departments of *Ophthalmology, †Radiation Oncology, and ‡Pathology, Academic Medical Center, University of Amsterdam, The Netherlands.

Ophthalmic Plastic and Reconstructive Surgery
|July 16, 2014
PubMed
Summary

Epithelioid sarcoma, a rare soft tissue cancer, can occur in the orbit. Surgical debulking combined with iridium radiation therapy offers a viable treatment option for orbital epithelioid sarcoma.

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Area of Science:

  • Oncology
  • Ophthalmology
  • Soft Tissue Pathology

Background:

  • Epithelioid sarcoma is a rare, aggressive soft tissue malignancy.
  • It typically affects young adults, often in the distal upper limbs.
  • Primary orbital epithelioid sarcoma is exceptionally rare, with limited documented cases.

Observation:

  • Only four prior case reports of primary orbital epithelioid sarcoma exist.
  • Previous treatments included radical surgical excision or exenteration, with variable outcomes.
  • One patient refused exenteration and underwent surgical debulking with local brachytherapy.

Findings:

  • The patient who refused exenteration remained tumor-free for 5 years post-treatment.
  • This suggests that surgical debulking combined with local iridium radiation therapy is effective.

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  • This approach is a viable alternative to more radical surgical interventions.

    • Implications:

    • Treatment options for primary orbital epithelioid sarcoma are limited.
    • Surgical excision and local iridium radiation therapy present an acceptable treatment strategy.
    • Further research is needed to establish optimal management protocols for this rare orbital tumor.