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Updated: Apr 27, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Clinical and histological evaluation of socket grafting using different types of bone substitute in adult patients
James Rudolph Collins1, Ely Jiménez, Carol Martínez
1*Professor and Director of Graduate Periodontics, Department of Periodontics, School of Dentistry, Pontificia Universidad Católica Madre y Maestra (PUCMM), Santo Domingo, Dominican Republic. †Resident, Department of Periodontology, Graduate School, Catholic University of Santo Domingo, Santo Domingo, Dominican Republic. ‡Professor and Director, Department of Prosthodontics, Graduate School, Catholic University of Santo Domingo, Santo Domingo, Dominican Republic. §Assistant Professor, Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, NY. ‖Undergraduate Student, New York University College of Dentistry, New York, NY. ¶Associate Professor, Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, NY; Director, Research Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York, NY; Affiliated Faculty, Division of Engineering, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates. #Assistant Professor, Department of Prosthodontics, Bauru College of Dentistry, University of São Paulo, Bauru, SP, Brazil. **Adjunct Professor, Director, Material Analysis and Testing Laboratory, Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, NY.
Purpose:
This clinical and histological study evaluated the healing of extraction sockets after implantation of a biphasic calcium sulfate (CS) alone or in combination with a gamma-radiated human mineralized allograft.
Materials And Methods:
Ten healthy adult patients participated in the study. A minimum of 2 teeth, per patient, extracted for different reasons were evaluated. Each socket was randomly filled to the crest with either (a) a biphasic CS or (b) large particulate gamma-radiated human mineralized allograft in combination with a biphasic CS.
Results:
No complications during reentry of the socket site during bone core retrieval, such as inflammation/immunogenic response, were observed. Histological findings showed a mean new bone (NB) of 33% for sockets filled with biphasic CS and 31% for sockets filled with biphasic CS in combination with allograft material. There was no statistically significant difference in the percentage of NB and the presence of soft tissue between graft materials.
Conclusion:
Biphasic CS used alone or in combination with an allograft resulted in the same amount of NB formation in alveolar ridge preservation procedures.
