[Effect of preliminary administration of alpha-tocopherol and intal on the course of experimental myocardial necrosis]

Morphofunctional state of myocardial capillary bed and serum creatine kinase were measured in 70 white rats with coronary arterial occlusion. Four-day pretreatment with alpha-tocopherol and, particularly, intal, was conductive to the improvement of micro-circulation in the ischemized myocardium via an increase in the number, exchange surface area and capacity of functional capillaries. This effect became manifest since day 1 after coronary arterial occlusion and was accompanied by a stabilization of the creatine kinase level. The fact that the effect of intal was of basically the same type, but more pronounced, as compared to that of alpha-tocopherol, might be due to both the similarity of the drugs in terms of nonspecific antioxidant effect and specific properties of intal which has a membrane-protective effect on the mast cell, normalizing its stress-induced activation.