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Updated: Apr 27, 2026

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
In vitro methods in drug transporter interaction assessment
Drug transporter proteins impact drug absorption, distribution, metabolism, and excretion (ADME). Optimized in vitro assays are crucial for predicting drug behavior and are increasingly used in drug development.
Area of Science:
- Pharmacology
- Biochemistry
- Drug Development
Background:
- Drug transporter proteins are key at pharmacological barriers, influencing drug ADME properties.
- In vitro assays for drug transporters are now standard tools.
- Regulatory bodies increasingly require these assays in drug development.
Purpose of the Study:
- To highlight the importance of drug transporters in ADME.
- To emphasize the role of in vitro transporter assays.
- To discuss the regulatory implications of transporter studies.
Main Methods:
- Utilizing in vitro assays to study drug transporter interactions.
- Analyzing molecular-level interactions of drugs with transporters.
- Predicting barrier penetration and pharmacokinetic profiles.
Main Results:
- Drug transporters significantly affect drug ADME.
- In vitro assays provide reliable data on transporter interactions.
- These assays aid in predicting drug pharmacokinetics.
Conclusions:
- Drug transporter assays are essential for modern drug development.
- Understanding transporter roles improves drug efficacy and safety.
- Regulatory acceptance of these assays is growing.
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