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Hyperpigmentation due to cyclosporin therapy

A J Brady1, A J Wing

  • 1Department of Renal Medicine, St Thomas' Hospital, London, UK.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|January 1, 1989
PubMed

Abstract:

A 51 year old diabetic man had a cadaveric renal transplant performed. Cyclosporin immunosuppressive therapy was commenced routinely. He developed hyperpigmentation of the skin during 3 months' therapy which became increasingly marked and resolved after cyclosporin therapy was discontinued.

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Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...

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