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[Thrombolytic agents: efficacy in relation to evolution time and dose].

L J García Frade, M C Torrado, M Loren

    Revista Clinica Espanola
    |February 1, 1989
    PubMed
    Summary

    This study compared the effectiveness of three clot-busting drugs: urokinase (UK), streptokinase (SK), and tissue-type plasminogen activator (t-PA). All agents demonstrated clot-lysing capabilities up to seven days post-formation, with t-PA showing efficiency at lower doses.

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    Area of Science:

    • Biochemistry
    • Pharmacology
    • Thrombosis Research

    Background:

    • Fibrinolytic agents are crucial for dissolving blood clots.
    • Understanding the comparative efficacy of different agents is vital for clinical application.
    • Assessing lytic activity over time is important for treatment strategies.

    Purpose of the Study:

    • To evaluate the in vitro efficacy of urokinase (UK), streptokinase (SK), and tissue-type plasminogen activator (t-PA).
    • To compare their lytic action on clots of varying ages (1, 3, and 7 days).
    • To quantify fibrin fragment production as an indicator of fibrinolysis.

    Main Methods:

    • In vitro assessment of clot lysis using dry clot weight and 125I-fibrinogen release.
    • Quantification of fibrin fragments, including D-D dimer, over 1, 3, and 7 days.

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  • Testing various doses of UK, SK, and t-PA.

    • Main Results:

    • Tissue-type plasminogen activator (t-PA) demonstrated efficiency at doses ranging from 100 to 0.8 IU/ml.
    • Equivalent lytic activity was observed for t-PA (40 IU/ml), SK (200 IU/ml), and UK (200 IU/ml) on clots aged 1, 3, and 7 days.
    • Highest fibrin fragment (D-D dimer) production was associated with t-PA and UK use.

    Conclusions:

    • All tested fibrinolytic agents (UK, SK, t-PA) exhibit in vitro lytic capacity for clots up to seven days old.
    • t-PA is effective at lower concentrations compared to SK and UK.
    • The choice of fibrinolytic agent may influence the extent of fibrin degradation.