Related Experiment Video

Updated: Apr 27, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Systemic sclerosis and the risk of tuberculosis

Shuo-Ming Ou¹, Wen-Chien Fan¹, Kun-Ta Chou¹

¹From the Division of Nephrology, the Division of Hematology and Oncology, and the Division of Gastroenterology, Department of Medicine, the Department of Neurology, Neurological Institute, the Department of Chest Medicine, and the Department of Family Medicine, Taipei Veterans General Hospital, Taipei; Division of Chest Medicine, Da-Chien General Hospital, Miaoli; School of Medicine, Institute of Clinical Medicine, Institute of Public Health, and Department of Internal Medicine, National Yang-Ming University; Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Shuang Ho Hospital; Department of Medicine, Taipei City Hospital Heping Fuyou Branch; Department of Anesthesiology, Wan Fang Hospital, Taipei Medical University, Taipei; Department of Emergency Medicine, National Yang-Ming University Hospital, Yilan, Taiwan.S-M. Ou, MD, Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, and School of Medicine, National Yang-Ming University; W-C. Fan, MD, Division of Chest Medicine, Da-Chien General Hospital, and School of Medicine, National Yang-Ming University; K-T. Cho, MD, Institute of Clinical Medicine, National Yang-Ming University, and Department of Chest Medicine, Taipei Veterans General Hospital; C-M. Yeh, MS, School of Medicine, National Yang-Ming University, and Department of Family Medicine, Taipei Veterans General Hospital; V.Y-F. Su, MD, Department of Chest Medicine, Taipei Veterans General Hospital; M-H. Hung, MD, Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital; Y-S. Chang, MD, School of Medicine, National Yang-Ming University, and Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Shuang Ho Hospital; Y-J. Lee, MD, School of Medicine, National Yang-Ming University, and Department of Neurology, Neurological Institute, Taipei Veterans General Hospital; Y-T. Chen, MD, Division of Nephrology, Department of Medicine, Taipei Vete

The Journal of Rheumatology

|July 17, 2014

Abstract

Objective:

Pulmonary involvement is common in patients with systemic sclerosis (SSc), and this condition causes substantial morbidity and mortality. Disrupted immunity from the disease or associated medication may render such patients subject to tuberculosis (TB) infection. However, the relationship between SSc and TB has not yet been investigated.

Methods:

Using the Taiwan National Health Insurance Research Database, 838 patients with SSc diagnosed in Taiwan during 2000-2006 were identified and followed for emergence of TB infection. Incidence rate ratios (IRR) of TB compared to 8380 randomly selected age-, sex-, and comorbidity-matched controls without SSc were calculated. The Cox proportional hazards model was used for multivariate adjustment to identify independent risk factors for TB infection.

Results:

The risk of TB infection was higher in the SSc cohort than in controls (IRR 2.81, 95% CI 1.36-5.37; p = 0.004), particularly for pulmonary TB (IRR 2.53, 95% CI 1.08-5.30; p = 0.022). Other independent risk factors for TB infection in patients with SSc were age ≥ 60 years [hazard ratio (HR) 3.52, 95% CI 1.10-11.33; p = 0.035] and pulmonary hypertension (PH; HR 6.06, 95% CI 1.59-23.17; p = 0.008). Mortality did not differ for SSc patients with or without TB.

Conclusion:

In this nationwide study, the incidence of TB infection was significantly higher among patients with SSc than in controls without SSc. Special care should be taken in managing patients with SSc who are at high risk for TB, especially those aged ≥ 60 years or who also have PH.

Keywords:

PULMONARY FIBROSIS PULMONARY HYPERTENSION SYSTEMIC SCLEROSIS TUBERCULOSIS

More Related Videos

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Related Concept Videos

Pulmonary Tuberculosis I

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

Pulmonary Tuberculosis III

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:

Pulmonary Tuberculosis II

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...

Pulmonary Tuberculosis IV

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...

Pulmonary Tuberculosis V

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...

Multiple Sclerosis l: Introduction

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

Articles linked to this work by shared authors, journal, and citation graph.

Real-world analysis of autologous stem cell transplantation in primary central nervous system lymphoma using Taiwan Blood and Marrow Transplantation Registry.

Journal of the Formosan Medical Association = Taiwan yi zhi·2026

Mezigdomide, carfilzomib, and dexamethasone versus carfilzomib and dexamethasone in patients with relapsed or refractory multiple myeloma (SUCCESSOR-2): a phase 3, open-label, randomised controlled trial.

Lancet (London, England)·2026

Thrombocytosis Phenotype in Prefibrotic Primary Myelofibrosis: Risk Stratification and Prognostic Significance.

Clinical lymphoma, myeloma & leukemia·2026

Classification of hematologic malignancies from whole-slide bone marrow aspirates using a two-stage deep convolutional neural network pipeline.

Digital health·2026

Optimizing the timing of lymphocyte collection after stem cell harvesting in B-cell lymphoma and myeloma patients.

Cytotherapy·2026

Dual-Stream Deep Feature and Cell Phenotype Fusion Model for the Diagnosis of Myeloproliferative Neoplasms.

Laboratory investigation; a journal of technical methods and pathology·2026

See all related articles