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Updated: Apr 26, 2026

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe
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Oxidative stress and vitiligo: the Nrf2-ARE signaling connection

Lei Qiu1, Zhiqi Song1, Vijayasaradhi Setaluri2

  • 1Department of Dermatology, First Affiliated Hospital of Dalian Medical University, Dalian, China.

The Journal of Investigative Dermatology
|July 17, 2014
PubMed

Insights

Vitiligo involves melanocyte sensitivity to oxidative stress. Impaired Nrf2 signaling and reduced antioxidant enzyme activity in vitiligo patients link redox imbalance to disease.

Area of Science:

  • Dermatology
  • Cell Biology
  • Immunology

Background:

  • Epidermal melanocytes are sensitive to oxidative stress, a factor implicated in vitiligo pathogenesis.
  • The precise molecular links between melanocyte redox balance and vitiligo's complex phenotype remain unclear.

Purpose of the Study:

  • To investigate the role of nuclear factor erythroid 2-related factor 2 (Nrf2) signaling and antioxidant enzyme activation in vitiligo melanocytes.
  • To explore correlations between serum interleukin-2 (IL-2) levels and hemeoxygenase-1 (HO-1) in vitiligo patients.

Main Methods:

  • Analysis of Nrf2-antioxidant response element (ARE) signaling in vitiligo melanocytes.
  • Assessment of antioxidant enzyme system activation.
  • Measurement of serum IL-2 and HO-1 levels in patients with vitiligo.

Main Results:

  • Vitiligo melanocytes exhibit impaired Nrf2-ARE signaling.
  • Decreased activation of the antioxidant enzyme system was observed in vitiligo melanocytes.
  • Higher serum IL-2 levels positively correlated with lower HO-1 levels in vitiligo patients.

Conclusions:

  • Impaired Nrf2 signaling and reduced antioxidant capacity contribute to vitiligo pathogenesis.
  • The observed correlation between IL-2 and HO-1 suggests a potential link between immune response and oxidative stress in vitiligo.

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