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Central nervous system manifestations of a valproic acid overdose responsive to naloxone
G Alberto1, T Erickson, R Popiel
1Department of Emergency Medicine, Cook County Hospital, Chicago, Illinois 60612.
Annals of Emergency Medicine
|August 1, 1989
Abstract:
We report the case of a 22-year-old man who presented with a depressed level of consciousness after ingesting valproic acid. He responded to IV naloxone; over a nine-hour period, his serum valproic acid level decreased from 180.4 to 59.2 micrograms/ml with multiple-dose charcoal therapy. We recommend the use of both agents in the treatment of valproic acid overdose.