Related Experiment Video
Updated: Apr 26, 2026
Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
Should we expand the concept of coronary heart disease equivalents?
Niki Katsiki1, Vasilios G Athyros, Asterios Karagiannis
1aSecond Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece bDepartment of Metabolic Medicine/Chemical Pathology, Guy's & St Thomas' Hospitals cDepartment of Clinical Biochemistry (Vascular Disease Prevention Clinics), Royal Free Hospital campus, University College London Medical School, University College London (UCL), London, UK.
Insights
Metabolic and inflammatory diseases, along with cancer treatments, increase coronary heart disease (CHD) risk. While not CHD equivalents, these conditions warrant further investigation for potential inclusion.
Area of Science:
- Cardiology
- Metabolic Diseases
- Inflammatory Diseases
- Oncology
Background:
- Coronary heart disease (CHD) remains a leading cause of mortality worldwide.
- Emerging evidence suggests links between metabolic/inflammatory conditions and cardiovascular risk.
- The role of cancer therapies in cardiovascular health is increasingly recognized.
Purpose of the Study:
- To review associations between metabolic and inflammatory diseases and CHD.
- To examine the impact of radiotherapy and chemotherapy on CHD risk.
- To evaluate the potential of these conditions as CHD equivalents.
Main Methods:
- Narrative review of existing literature.
- Analysis of studies on metabolic syndrome, diabetes, NAFLD, sleep apnea, erectile dysfunction, periodontitis, IBD, vasculitis, and HIV.
- Inclusion of data on chemotherapy and radiotherapy effects.
Main Results:
- Metabolic and inflammatory disorders are linked to increased CHD morbidity and mortality.
- Conditions like metabolic syndrome, impaired glucose metabolism, NAFLD, and others show significant associations.
- Chemotherapy and radiotherapy also correlate with elevated CHD risk.
Conclusions:
- While not currently classified as CHD equivalents, these conditions significantly elevate cardiovascular risk.
- Further research is needed to determine if specific conditions should be added to the list of CHD equivalents.
- Identifying new CHD equivalents can refine risk stratification and prevention strategies.
Purpose Of Review:
This narrative review discusses the associations between metabolic and inflammatory diseases, as well as radiotherapy and chemotherapy with coronary heart disease (CHD) and related risk factors, to support (or not) their potential role as CHD equivalents.
Recent Findings:
Although not regarded as CHD equivalents, several metabolic and inflammatory disorders are associated with an increased risk of CHD morbidity and/or mortality. These conditions include metabolic syndrome, impaired glucose metabolism, nonalcoholic fatty liver disease, obstructive sleep apnoea syndrome, erectile dysfunction, periodontitis, inflammatory bowel diseases, systemic vasculitis and HIV infection, as well as chemotherapy and radiotherapy.
Summary:
More research should be carried out to identify which conditions can be added to the list of CHD equivalents.
More Related Videos
Related Concept Videos
01:30Coronary Artery Disease I: Introduction
01:26Coronary Artery Disease II: Pathophysiology
01:30Coronary Artery Disease III: Clinical Manifestations
01:26Coronary Artery Disease IV: Preventive Measures
01:17Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
01:27Coronary Artery Disease V: Interprofessional Care