Related Experiment Video
Updated: Apr 26, 2026
09:34
An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
2.1K
Association between serum selenium level and conversion of bacteriological tests during antituberculosis treatment
Milena Lima de Moraes1, Daniela Maria de Paula Ramalho2, Karina Neves Delogo2
1McGill University, Montreal, QC, Canada.
Summary
Higher serum selenium levels after 60 days of treatment are linked to successful bacteriological test conversion in pulmonary tuberculosis patients. This finding highlights selenium
Area of Science:
- Nutritional biochemistry
- Infectious diseases
- Clinical medicine
Background:
- Pulmonary tuberculosis (TB) is a significant global health challenge.
- Nutritional status, including trace element levels, may influence TB treatment outcomes.
- Selenium is an essential trace element with immune-modulating properties.
Purpose of the Study:
- To investigate the association between serum selenium levels and bacteriological conversion in pulmonary TB patients.
- To explore the relationship between selenium and treatment response after eight weeks of standard therapy.
Main Methods:
- A case-control study involving 35 pulmonary TB patients and 35 healthy controls.
- Measurement of serum selenium, albumin, and C-reactive protein (CRP) at baseline, 30, and 60 days of treatment.
- Assessment of anthropometric indices and sputum microscopy/culture for bacteriological conversion.
Main Results:
- Pulmonary TB patients exhibited lower baseline serum selenium levels compared to controls.
- Bacteriological test conversion at 60 days was associated with the CRP/albumin ratio and serum selenium levels.
- A significant proportion of TB patients presented with malnutrition and unhealthy lifestyle factors.
Conclusions:
- Elevated serum selenium levels at 60 days of treatment correlate with successful bacteriological conversion in pulmonary TB.
- Selenium status may play a role in the treatment efficacy of pulmonary tuberculosis.
More Related Videos
11:28Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques
Published on: March 13, 2015
46.1K
12:39Antimicrobial Susceptibility Testing of Mycobacterium Tuberculosis Complex for First and Second Line Drugs by Broth Dilution in a Microtiter Plate Format
Published on: June 24, 2011
39.7K
Related Concept Videos
01:26Pulmonary Tuberculosis IV
810
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
810
01:28Pulmonary Tuberculosis V
978
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
978
01:31Pulmonary Tuberculosis III
1.7K
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
1.7K
01:29Pulmonary Tuberculosis I
1.7K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.7K
01:24Serum Studies: Renal Function Tests
671
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
671
01:30Serum Laboratory Studies, Stool Test, Breath Test
1.2K
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
1.2K