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Updated: Apr 26, 2026
11:30
A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
1.8K
[Vascular calcification in chronic kidney disease]
Summary
Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) face higher cardiovascular risks due to traditional and non-traditional factors. Coronary artery calcification (CAC) is a key non-traditional risk, assessed via noninvasive imaging.
Area of Science:
- Nephrology and Cardiology
- Medical Imaging
Context:
- Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) exhibit elevated cardiovascular (CV) risk compared to the general population.
- This heightened risk stems from both traditional CV risk factors and unique non-traditional factors associated with renal impairment.
Purpose:
- To review the significance of coronary artery calcification (CAC) as a critical non-traditional CV risk factor in CKD and ESRD patients.
- To discuss the various noninvasive imaging modalities employed for detecting, quantifying, and monitoring CAC progression in this vulnerable population.
Summary:
- Coronary artery calcification (CAC) is increasingly recognized as a major non-traditional cardiovascular risk factor in individuals with chronic kidney disease (CKD) or end-stage renal disease (ESRD).
- Noninvasive imaging techniques provide essential tools for assessing the presence, extent, and progression of CAC, aiding in risk stratification and management.
- This review highlights the importance of CAC and outlines the commonly utilized noninvasive methods for its evaluation in CKD/ESRD patients.
Impact:
- Enhances understanding of cardiovascular disease mechanisms in CKD/ESRD.
- Informs clinical practice regarding risk assessment and patient monitoring for cardiovascular events.
- Promotes the use of advanced imaging for better management of CKD/ESRD patients at high cardiovascular risk.
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