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Thorax: normal and benign pathologic patterns in FDG-PET/CT imaging.

Jason W Wachsmann1, Victor H Gerbaudo2

  • 1Joint Program in Nuclear Medicine, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

PET Clinics
|July 18, 2014
PubMed
Summary

This article details normal thoracic (18)F-fluorodeoxyglucose (FDG) uptake patterns. Understanding benign FDG-PET/CT findings is crucial for accurate chest disorder diagnosis.

Keywords:
(18)F-Fluorodeoxyglucose PETBenign pathologic findingsComputed tomographyInfectionInflammationNormal biodistributionThorax

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Area of Science:

  • Nuclear Medicine
  • Radiology
  • Thoracic Imaging

Background:

  • Positron Emission Tomography (PET) with computed tomography (CT) is a key imaging modality.
  • (18)F-fluorodeoxyglucose (FDG) uptake reflects metabolic activity.
  • Accurate interpretation requires knowledge of normal biodistribution and potential pitfalls.

Purpose of the Study:

  • To describe normal thoracic (18)F-fluorodeoxyglucose (FDG) biodistribution.
  • To review the role of FDG-PET/CT in evaluating benign chest conditions.
  • To aid in the accurate interpretation of FDG-PET/CT scans in clinical practice.

Main Methods:

  • Review of literature on thoracic FDG-PET/CT imaging.
  • Description of normal FDG biodistribution patterns in the chest.
  • Discussion of common benign causes of increased FDG uptake.

Main Results:

  • Established patterns of normal FDG uptake in thoracic organs and tissues.
  • Identified various benign conditions that can cause increased FDG uptake.
  • Highlighted the importance of differentiating benign from malignant uptake.

Conclusions:

  • Knowledge of normal thoracic FDG biodistribution is essential for interpreting PET/CT scans.
  • Understanding nonmalignant causes of increased FDG uptake minimizes misdiagnosis.
  • FDG-PET/CT is valuable for evaluating a range of benign chest pathologies.