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Updated: Apr 26, 2026

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
Published on: October 14, 2025
[Therapy of chronic inflammatory bowel diseases. Standards, controversies and perspectives]
K Herrlinger1, K Fellermann, E F Stange
1Abteilung Innere Medizin 1, Asklepios Klinik Nord, Standort Heidberg, Tangstedter Landstr. 400, 22417, Hamburg, Deutschland, k.herrlinger@asklepios.com.
Abstract:
Crohn's disease and ulcerative colitis are the most common forms of chronic inflammatory bowel disease. The therapeutic algorithm is complex and individualized especially in complicated courses of the disease. This article gives a comprehensive overview on the typical courses of disease and the standard therapy of both diseases. Furthermore, ongoing controversies will be highlighted including early immunosuppression and immunomodulation as well as new therapeutic goals, such as mucosal healing. Finally, a perspective on future therapeutic options is given focusing especially on vedolizumab, the new antibody against the bowel-specific α4β7-integrin.
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