[Analysis of the effect of risk factors at gestational diabetes mellitus]

To assesment the effect of risk factors at gestational diabetes mellitus (GDM).

We collected 427 pregnant women who had done 75 g oral glucose tolerance test (OGTT) between September 1(st), 2012 and April 19(th), 2013 in Peking University First Hospital, including 74 pregnant women diagnosed as GDM (GDM group) and 353 pregnant women undiagnosed (non-GDM group). Then we conducted a multiple logistic regression to analyze the clinical datas collected from two groups, which included age, pre-pregnancy body weight and body mass index (BMI), body weight during 11-12 weeks pregnancy, body weight during 23-24 weeks pregnancy; and fasting plasma glucose (FPG), triglyceride (TG) , total cholesterol (TCH) , high density lipoprotein (HDL) , low density lipoprotein (LDL), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR) during early pregnancy; and family history of diabetes mellitus.

(1) There were significant difference in age, pre-pregnancy BMI, and FPG, TG, FINS, HOMA-IR during early pregnancy, and family history of diabetes mellitus between two groups (P < 0.05). (2) The risk factors of GDM that have statistical significance included FPG during early pregnancy (OR:4.03, 95%CI:1.62-10.02), family history of diabetes mellitus (OR:3.15, 95%CI:1.66-5.99), TG during early pregnancy (OR:2.13, 95%CI:1.17-3.87),BMI before pregnancy (OR:1.36, 95%CI:1.08-1.70), age ≥ 35 years (OR:1.15, 95%CI:1.05-1.26), early pregnancy weight gain (OR:1.20, 95%CI:1.06-1.35), mid pregnancy weight gain (OR:1.28, 95%CI:1.12-1.47), FINS during early pregnancy (OR:1.09, 95%CI:1.01-1.17).

FPG, TG and FINS during early pregnancy, BMI before pregnancy, early and mid pregnancy weight gain, family history of diabetes mellitus and age ≥ 35 years are the indepadent risk factors for GDM. We should pay more attention to FPG and TG during early pregnancy, and put weight management into practise since early pregnancy and try to control pregnancy weight gain within reasonable limits.