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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Related Experiment Video

Updated: Apr 26, 2026

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
06:03

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Published on: May 9, 2025

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Bleomycin-induced flagellate dermatitis.

Guilherme Devidé Mota1, Adriana Marques Damasco Penna1, Regina Cláudia Soares1

  • 1Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.

Revista Brasileira De Hematologia E Hemoterapia
|July 18, 2014
PubMed
Summary

A patient with advanced Hodgkin's lymphoma developed a flagellate rash after chemotherapy. Symptoms resolved with prednisone and stopping bleomycin, indicating a drug-induced reaction.

Keywords:
BleomycinDrug eruptionsErythema

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Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Hodgkin's lymphoma is a cancer of the lymphatic system.
  • Chemotherapy regimens like ABVD are standard for Hodgkin's lymphoma.
  • Adverse drug reactions can complicate cancer treatment.

Purpose of the Study:

  • To report a rare cutaneous side effect of ABVD chemotherapy.
  • To describe the clinical presentation and management of a flagellate rash.
  • To highlight the potential role of bleomycin in drug-induced dermatoses.

Main Methods:

  • Case report of a 29-year-old woman with stage IVB Hodgkin's lymphoma.
  • Administration of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy.
  • Clinical observation of dermatological adverse events and response to treatment.

Main Results:

  • The patient developed pruritic, linear, erythematous lesions in a flagellate pattern.
  • The rash appeared two weeks after the first cycle of ABVD.
  • Lesions resolved after initiating oral prednisone and discontinuing bleomycin.

Conclusions:

  • Flagellate dermatosis is a potential adverse reaction to ABVD chemotherapy, particularly bleomycin.
  • Prompt recognition and management, including drug cessation and corticosteroid use, can lead to resolution.
  • This case underscores the importance of monitoring for cutaneous side effects during cancer therapy.