Related Experiment Video
Updated: Apr 26, 2026
Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
Published on: April 11, 2025
White matter correlates of cognitive dysfunction after mild traumatic brain injury
Iain D Croall1, Christopher J A Cowie2, Jiabao He2
1From the Institute of Cellular Medicine & Newcastle MR Centre (I.D.C., C.J.A.C., J.W., F.E.S., A.M.B.), Newcastle University; Departments of Neurosurgery (C.J.A.C., P.M., A.D.M.) and Neuropsychology (T.K.), Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne; Aberdeen Biomedical Imaging Centre (J.H.), School of Medicine and Dentistry, University of Aberdeen; Department of Psychology (A.P.), Durham University; Brain Research Imaging Centre (B.S.A.), Neuroimaging Sciences, University of Edinburgh; and NeuroCog (D.M.), John Buddle Village, Newcastle upon Tyne, UK. i.d.croall@newcastle.ac.uk.
Objective:
To relate neurophysiologic changes after mild/moderate traumatic brain injury to cognitive deficit in a longitudinal diffusion tensor imaging investigation.
Methods:
Fifty-three patients were scanned an average of 6 days postinjury (range = 1-14 days). Twenty-three patients were rescanned 1 year later. Thirty-three matched control subjects were recruited. At the time of scanning, participants completed cognitive testing. Tract-Based Spatial Statistics was used to conduct voxel-wise analysis on diffusion changes and to explore regressions between diffusion metrics and cognitive performance.
Results:
Acutely, increased axial diffusivity drove a fractional anisotropy (FA) increase, while decreased radial diffusivity drove a negative regression between FA and Verbal Letter Fluency across widespread white matter regions, but particularly in the ascending fibers of the corpus callosum. Raised FA is hypothesized to be caused by astrogliosis and compaction of axonal neurofilament, which would also affect cognitive functioning. Chronically, FA was decreased, suggesting myelin sheath disintegration, but still regressed negatively with Verbal Letter Fluency in the anterior forceps.
Conclusions:
Acute mild/moderate traumatic brain injury is characterized by increased tissue FA, which represents a clear neurobiological link between cognitive dysfunction and white matter injury after mild/moderate injury.
